Poliovirus receptor-related 2

NECTIN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3R0N, 4DFH, 4DFI, 4HZA
Identifiers
Aliases	NECTIN2, CD112, HVEB, PRR2, PVRR2, PVRL2, nectin cell adhesion molecule 2
External IDs	OMIM: 600798; MGI: 97822; HomoloGene: 86092; GeneCards: NECTIN2; OMA:NECTIN2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	44,889,223 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	19,484,408 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; olfactory zone of nasal mucosa; ; apex of heart; ; right lobe of liver; ; gallbladder; ; right testis; ; left adrenal cortex; ; body of stomach; ; mucosa of transverse colon; ; upper lobe of left lung;
	Top expressed in
	yolk sac; ; transitional epithelium of urinary bladder; ; Ileal epithelium; ; decidua; ; gastrula; ; lumbar spinal ganglion; ; endothelial cell of lymphatic vessel; ; duodenum; ; epiblast; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	coreceptor activity; virus receptor activity; protein binding; identical protein binding; signaling receptor binding; cell adhesion molecule binding; protein heterodimerization activity; protein homodimerization activity;
Cellular component	integral component of membrane; membrane; cell-cell junction; focal adhesion; plasma membrane; integral component of plasma membrane; cell surface; zonula adherens; extracellular exosome; apical junction complex; cell-cell contact zone;
Biological process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; sperm mitochondrion organization; cell recognition; positive regulation of immunoglobulin mediated immune response; regulation of viral entry into host cell; susceptibility to natural killer cell mediated cytotoxicity; positive regulation of mast cell activation; cell adhesion; acrosome assembly; cytoskeleton organization; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; cilium organization; establishment of mitochondrion localization; spermatid development; regulation of immune response; fertilization; spermatid nucleus differentiation; susceptibility to T cell mediated cytotoxicity; viral process; cell part morphogenesis; adherens junction organization; positive regulation of natural killer cell mediated cytotoxicity; homophilic cell adhesion via plasma membrane adhesion molecules; viral entry into host cell; signal transduction; positive regulation of T cell receptor signaling pathway; virion attachment to host cell;
	Sources:Amigo / QuickGO
Orthologs
	5819
	19294
	ENSG00000130202
	ENSMUSG00000062300
	Q92692
	P32507
	NM_001042724; NM_002856
	NM_001159724; NM_008990
	NP_001036189; NP_002847
	NP_001153196; NP_033016
	Wikidata
View/Edit Human	View/Edit Mouse

Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), is a human plasma membrane glycoprotein.