CADPS

CADPS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WI1
Identifiers
Aliases	CADPS, CADPS1, CAPS, CAPS1, UNC-31, Ca2+ dependent secretion activator, calcium dependent secretion activator
External IDs	OMIM: 604667; MGI: 1350922; HomoloGene: 2755; GeneCards: CADPS; OMA:CADPS - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	62,875,416 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	12,823,079 bp
RNA expression pattern
	Top expressed in
	Pons; ; Brodmann area 46; ; prefrontal cortex; ; Brodmann area 9; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; right frontal lobe; ; superior frontal gyrus; ; postcentral gyrus;
	Top expressed in
	pontine nuclei; ; medial vestibular nucleus; ; dorsal tegmental nucleus; ; deep cerebellar nuclei; ; mammillary body; ; ventral tegmental area; ; dorsomedial hypothalamic nucleus; ; superior colliculus; ; medial geniculate nucleus; ; lateral geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein kinase binding; metal ion binding; lipid binding;
Cellular component	membrane; cytoplasmic vesicle; cytosol; cell junction; synapse; cytoplasmic vesicle membrane; presynapse; glutamatergic synapse;
Biological process	protein transport; synaptic vesicle priming; catecholamine secretion; vesicle organization; exocytosis; synaptic vesicle exocytosis; dense core granule exocytosis; presynaptic dense core vesicle exocytosis; positive regulation of exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	8618
	27062
	ENSG00000163618
	ENSMUSG00000054423
	Q9ULU8
	Q80TJ1
	NM_003716; NM_183393; NM_183394
	NM_001042617; NM_012061; NM_001359919; NM_001359920; NM_001359921
	NP_003707; NP_899630; NP_899631
	NP_001036082; NP_036191; NP_001346848; NP_001346849; NP_001346850
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium-dependent secretion activator 1 is a protein that in humans is encoded by the CADPS gene.

CADPS encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. CADPS acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.