Cav1.3

CACNA1D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LV3
Identifiers
Aliases	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, PASNA, SANDD, calcium voltage-gated channel subunit alpha1 D
External IDs	OMIM: 114206; MGI: 88293; HomoloGene: 578; GeneCards: CACNA1D; OMA:CACNA1D - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	53,813,733 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	30,213,412 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; right lung; ; sural nerve; ; right adrenal gland; ; islet of Langerhans; ; right adrenal cortex; ; left adrenal cortex; ; pituitary gland; ; right uterine tube; ; testicle;
	Top expressed in
	pituitary gland; ; superior frontal gyrus; ; substantia nigra; ; utricle; ; islet of Langerhans; ; primary visual cortex; ; pineal gland; ; stria vascularis; ; suprachiasmatic nucleus; ; vas deferens;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; voltage-gated ion channel activity; high voltage-gated calcium channel activity; ion channel activity; voltage-gated calcium channel activity involved in cardiac muscle cell action potential; alpha-actinin binding; ankyrin binding; voltage-gated calcium channel activity; voltage-gated calcium channel activity involved SA node cell action potential; calcium channel activity; voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels;
Cellular component	voltage-gated calcium channel complex; L-type voltage-gated calcium channel complex; integral component of membrane; membrane; plasma membrane; Z discdkac; cochlear hair cell ribbon synapse; integral component of presynaptic active zone membrane;
Biological process	regulation of atrial cardiac muscle cell membrane repolarization; regulation of insulin secretion; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; calcium ion import; regulation of ion transmembrane transport; ion transport; calcium ion transmembrane transport; transmembrane transport; regulation of potassium ion transmembrane transporter activity; membrane depolarization during cardiac muscle cell action potential; regulation of potassium ion transmembrane transport; calcium ion transport; positive regulation of calcium ion transport; hearing; cardiac muscle cell action potential involved in contraction; membrane depolarization during SA node cell action potential; regulation of heart rate by cardiac conduction; positive regulation of presynaptic cytosolic calcium concentration; induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration; positive regulation of adenylate cyclase activity; cardiac conduction;
	Sources:Amigo / QuickGO
Orthologs
	776
	12289
	ENSG00000157388
	ENSMUSG00000015968
	Q01668
	Q99246
	NM_000720; NM_001128839; NM_001128840
	NM_001083616; NM_028981; NM_001302637
	NP_000711; NP_001122311; NP_001122312
	NP_001077085; NP_001289566; NP_083257
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium channel, voltage-dependent, L type, alpha 1D subunit (also known as Ca_v1.3) is a protein that in humans is encoded by the CACNA1D gene. Ca_v1.3 channels belong to the Ca_v1 family, which form L-type calcium currents and are sensitive to selective inhibition by dihydropyridines (DHP).