CACNA1B

CACNA1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LCM
Identifiers
Aliases	CACNA1B, BIII, CACNL1A5, CACNN, Cav2.2, DYT23, calcium voltage-gated channel subunit alpha1 B, NEDNEH
External IDs	OMIM: 601012; MGI: 88296; HomoloGene: 20184; GeneCards: CACNA1B; OMA:CACNA1B - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	138,124,624 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	24,653,164 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; postcentral gyrus; ; endothelial cell; ; superior frontal gyrus; ; entorhinal cortex; ; right hemisphere of cerebellum; ; primary visual cortex; ; Brodmann area 46; ; cerebellar vermis;
	Top expressed in
	supraoptic nucleus; ; ventromedial nucleus; ; dorsomedial hypothalamic nucleus; ; anterior amygdaloid area; ; trigeminal ganglion; ; gastrula; ; subiculum; ; arcuate nucleus; ; lumbar spinal ganglion; ; mammillary body;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein C-terminus binding; metal ion binding; nucleotide binding; calcium ion binding; voltage-gated calcium channel activity; high voltage-gated calcium channel activity; ion channel activity; ATP binding; voltage-gated ion channel activity; protein binding; calcium channel activity; amyloid-beta binding;
Cellular component	integral component of membrane; presynapse; membrane; soma; dendrite; voltage-gated calcium channel complex; plasma membrane;
Biological process	calcium ion transport; chemical synaptic transmission; transmembrane transport; membrane depolarization during action potential; locomotory behavior; regulation of ion transmembrane transport; regulation of blood pressure; regulation of calcium ion transport; ion transport; regulation of heart contraction; calcium ion transmembrane transport; response to pain; membrane depolarization; neurotransmitter secretion; calcium ion import; modulation of chemical synaptic transmission; response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologs
	774
	12287
	ENSG00000148408
	ENSMUSG00000004113
	Q00975
	O55017
	NM_000718; NM_001243812
	NM_001042528; NM_007579
	NP_000709; NP_001230741
	NP_001035993; NP_031605
	Wikidata
View/Edit Human	View/Edit Mouse

The voltage-dependent N-type calcium channel subunit alpha-1B is a protein that in humans is encoded by the CACNA1B gene. The α1B protein, together with β and α2δ subunits forms N-type calcium channel (Ca_v2.2 channel). It is an R-type calcium channel.