Carbonic anhydrase 9

CA9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HKF, 3IAI, 5FL4, 5FL5, 5FL6
Identifiers
Aliases	CA9, CAIX, MN, carbonic anhydrase 9
External IDs	OMIM: 603179; MGI: 2447188; HomoloGene: 20325; GeneCards: CA9; OMA:CA9 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	35,681,159 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	43,513,729 bp
RNA expression pattern
	Top expressed in
	body of stomach; ; gallbladder; ; fundus; ; cardia; ; cerebellar hemisphere; ; gonad; ; right hemisphere of cerebellum; ; right testis; ; pylorus; ; left testis;
	Top expressed in
	epithelium of stomach; ; mucous cell of stomach; ; zygote; ; pyloric antrum; ; primary oocyte; ; duodenum; ; secondary oocyte; ; large intestine; ; jejunum; ; colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; lyase activity; zinc ion binding; carbonate dehydratase activity; protein binding; carbonic anhydrase;
Cellular component	nucleolus; cell projection; nucleus; membrane; basolateral plasma membrane; microvillus membrane; integral component of membrane; plasma membrane;
Biological process	response to hypoxia; bicarbonate transport; morphogenesis of an epithelium; secretion; response to testosterone; regulation of transcription from RNA polymerase II promoter in response to hypoxia;
	Sources:Amigo / QuickGO
Orthologs
	768
	230099
	ENSG00000107159
	ENSMUSG00000028463
	Q16790
	Q8VHB5
	NM_001216
	NM_139305
	NP_001207
	NP_647466
	Wikidata
View/Edit Human	View/Edit Mouse

Carbonic anhydrase IX (CA9/CA IX) is an enzyme that in humans is encoded by the CA9 gene. It is one of the 14 carbonic anhydrase isoforms found in humans and is a transmembrane dimeric metalloenzyme with an extracellular active site that facilitates acid secretion in the gastrointestinal tract. CA IX is overexpressed in many types of cancer including clear cell renal cell carcinoma (RCC) as well as carcinomas of the cervix, breast and lung where it promotes tumor growth by enhancing tumor acidosis.