BTRC (gene)

BTRC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1P22, 2P64
Identifiers
Aliases	BTRC, BETA-TRCP, FBW1A, FBXW1, FBXW1A, FWD1, bTrCP, bTrCP1, betaTrCP, beta-transducin repeat containing E3 ubiquitin protein ligase
External IDs	OMIM: 603482; MGI: 1338871; HomoloGene: 39330; GeneCards: BTRC; OMA:BTRC - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	101,557,321 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	45,518,452 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; postcentral gyrus; ; superior frontal gyrus; ; entorhinal cortex; ; superior vestibular nucleus; ; lateral nuclear group of thalamus; ; pars compacta; ; prefrontal cortex; ; middle temporal gyrus; ; internal globus pallidus;
	Top expressed in
	spermatocyte; ; spermatid; ; blastocyst; ; neural layer of retina; ; morula; ; seminiferous tubule; ; superior frontal gyrus; ; primary oocyte; ; dentate gyrus of hippocampal formation granule cell; ; zygote;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; ligase activity; protein phosphorylated amino acid binding; protein dimerization activity; beta-catenin binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; snoRNA binding;
Cellular component	nucleus; cytoplasm; nucleoplasm; cytosol; SCF ubiquitin ligase complex; small-subunit processome; Pwp2p-containing subcomplex of 90S preribosome;
Biological process	cellular response to organic cyclic compound; protein destabilization; regulation of cell cycle; protein catabolic process; G2/M transition of mitotic cell cycle; negative regulation of DNA-binding transcription factor activity; regulation of I-kappaB kinase/NF-kappaB signaling; stress-activated MAPK cascade; negative regulation of transcription, DNA-templated; positive regulation of proteolysis; regulation of proteasomal protein catabolic process; regulation of circadian rhythm; mammary gland epithelial cell proliferation; branching involved in mammary gland duct morphogenesis; negative regulation of smoothened signaling pathway; rhythmic process; NIK/NF-kappaB signaling; signal transduction; ubiquitin-dependent protein catabolic process; regulation of canonical Wnt signaling pathway; protein dephosphorylation; positive regulation of transcription, DNA-templated; protein ubiquitination; positive regulation of circadian rhythm; Wnt signaling pathway; protein polyubiquitination; viral process; post-translational protein modification; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; interleukin-1-mediated signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); regulation of mitotic cell cycle phase transition; stimulatory C-type lectin receptor signaling pathway; Fc-epsilon receptor signaling pathway; T cell receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8945
	12234
	ENSG00000166167
	ENSMUSG00000025217
	Q9Y297; Q5T1W7
	Q3ULA2
	NM_001256856; NM_003939; NM_033637
NM_001037758; NM_001286465; NM_001286466; NM_009771; NM_001360120;
	NM_001360122; NM_001360124; NM_001360126; NM_001360127
	NP_001243785; NP_003930; NP_378663
NP_001032847; NP_001273394; NP_001273395; NP_033901; NP_001347049;
	NP_001347051; NP_001347053; NP_001347055; NP_001347056
	Wikidata
View/Edit Human	View/Edit Mouse

F-box/WD repeat-containing protein 1A (FBXW1A) also known as βTrCP1 or Fbxw1 or hsSlimb or pIkappaBalpha-E3 receptor subunit is a protein that in humans is encoded by the BTRC (beta-transducin repeat containing) gene.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 residue structural motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (Skp1-Cul1-F-box protein), which often, but not always, recognize substrates in a phosphorylation-dependent manner. F-box proteins are divided into 3 classes:

Fbxws containing WD40 repeats,
Fbxls containing leucine-rich repeats,
and Fbxos containing either "other" protein–protein interaction modules or no recognizable motifs.

The protein encoded by this gene belongs to the Fbxw class as, in addition to an F-box, this protein contains multiple WD40 repeats. This protein is homologous to Xenopus βTrCP, yeast Met30, Neurospora Scon2 and Drosophila Slimb. In mammals, in addition to βTrCP1, a paralog protein (called βTrCP2 or FBXW11) also exists, but, so far, their functions appear redundant and indistinguishable.