BAG3

BAG3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UK5
Identifiers
Aliases	BAG3, BAG-3, BIS, CAIR-1, MFM6, BCL2 associated athanogene 3, BAG cochaperone 3
External IDs	OMIM: 603883; MGI: 1352493; HomoloGene: 3162; GeneCards: BAG3; OMA:BAG3 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	119,677,819 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	128,148,705 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; Skeletal muscle tissue of rectus abdominis; ; body of tongue; ; glutes; ; muscle of thigh; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; tibialis anterior muscle; ; triceps brachii muscle; ; vena cava;
	Top expressed in
	cardiac muscle tissue of left ventricle; ; gastrula; ; muscle of thigh; ; ankle; ; plantaris muscle; ; interventricular septum; ; right ventricle; ; soleus muscle; ; extraocular muscle; ; digastric muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	chaperone binding; protein binding; adenyl-nucleotide exchange factor activity; cadherin binding; protein-containing complex binding;
Cellular component	cytosol; plasma membrane; Z discdkac; neuron projection; nucleus; cytoplasm;
Biological process	negative regulation of striated muscle cell apoptotic process; protein stabilization; negative regulation of apoptotic process; cellular response to mechanical stimulus; brain development; protein folding; spinal cord development; extrinsic apoptotic signaling pathway in absence of ligand; regulation of cellular response to heat; extrinsic apoptotic signaling pathway via death domain receptors; apoptotic process; regulation of catalytic activity; cellular response to heat; positive regulation of protein export from nucleus; negative regulation of transcription from RNA polymerase II promoter in response to stress; positive regulation of protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	9531
	29810
	ENSG00000151929
	ENSMUSG00000030847
	O95817
	Q9JLV1
	NM_004281
	NM_013863
	NP_004272
	NP_038891
	Wikidata
View/Edit Human	View/Edit Mouse

BAG family molecular chaperone regulator 3 is a protein that in humans is encoded by the BAG3 gene. BAG3 is involved in chaperone-assisted selective autophagy.