Angiofibroma

Angiofibroma
Angiofibroma, Hematoxylin and eosin stain, magnification ×10.
SpecialtyOncology 
SymptomsItchiness and sometimes bleeding.
ComplicationsFacial disfigurement and stigmatization.
CausesLocal overgrowth of collagen, fibroblasts, and blood vessels.
Risk factorsTuberous sclerosis, Birt-Hogg-Dubé syndrome, and Multiple endocrine neoplasia type 1.
Diagnostic methodSkin biopsy.
Differential diagnosisIntradermal melanocytic naevus, Acne, Basal cell carcinoma, Viral warts, Subungual exostosis, Molluscum contagiosum, and Anogenital warts.
TreatmentExcision, Dermabrasion, Using lasers, electrical, and radiofrequency devices, Cryotherapy, Topical podophyllotoxin, Topical rapamycin, and Topical beta-blockers.

Angiofibroma (AGF) is a descriptive term for a wide range of benign skin or mucous membrane (i.e. the outer membrane lining body cavities such as the mouth and nose) lesions in which individuals have:

  1. benign papules, i.e. pinhead-sized elevations that lack visible evidence of containing fluid;
  2. nodules, i.e. small firm lumps usually > 1 mm in diameter; and/or
  3. tumors, i.e. masses often regarded as ~8 mm or larger.
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