Altinicline

Altinicline
Clinical data
ATC code	None;
Identifiers
	IUPAC name (2S)-3-ethynyl-5-(1-methylpyrrolidin-2-yl)pyridine;
CAS Number	179120-92-4 ;
PubChem CID	3036156;
ChemSpider	2300234 ;
UNII	RJ9V9V09VM;
ChEMBL	ChEMBL111659 ;
CompTox Dashboard (EPA)	DTXSID40870143 ;
Chemical and physical data
Formula	C12H14N2
Molar mass	186.258 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c2ncc(C#C)cc2C1CCCN1C;
	InChI InChI=1S/C12H14N2/c1-3-10-7-11(9-13-8-10)12-5-4-6-14(12)2/h1,7-9,12H,4-6H2,2H3/t12-/m0/s1 ; Key:NUPUDYKEEJNZRG-LBPRGKRZSA-N ;
	(verify)

Altinicline (SIB-1508Y, SIB-1765F) is a drug which acts as an agonist at neural nicotinic acetylcholine receptors with high selectivity for the α4β2 subtype. It stimulates release of dopamine and acetylcholine in the brain in both rodent and primate models, and progressed as far as Phase II clinical trials for Parkinson's disease, where "no antiparkinsonian or cognitive-enhancing effects were demonstrated", although its current status is unclear.

Clinical data

ATC code	None
Identifiers
IUPAC name (2S)-3-ethynyl-5-(1-methylpyrrolidin-2-yl)pyridine
CAS Number	179120-92-4^Y
PubChem CID	3036156
ChemSpider	2300234^Y
UNII	RJ9V9V09VM
ChEMBL	ChEMBL111659^Y
CompTox Dashboard (EPA)	DTXSID40870143
Chemical and physical data
Formula	C₁₂H₁₄N₂
Molar mass	186.258 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES c2ncc(C#C)cc2C1CCCN1C
InChI InChI=1S/C12H14N2/c1-3-10-7-11(9-13-8-10)12-5-4-6-14(12)2/h1,7-9,12H,4-6H2,2H3/t12-/m0/s1^Y Key:NUPUDYKEEJNZRG-LBPRGKRZSA-N^Y
(verify)