Adipocyte protein 2

FABP4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NNT, 1TOU, 1TOW, 2HNX, 2NNQ, 3FR2, 3FR4, 3FR5, 3P6C, 3P6D, 3P6E, 3P6F, 3P6G, 3P6H, 3Q6L, 3RZY, 4NNS, 5EDB, 5EDC, 5D48, 5D4A, 5D45, 5D47
Identifiers
Aliases	FABP4, A-FABP, AFABP, ALBP, HEL-S-104, aP2, fatty acid binding protein 4
External IDs	OMIM: 600434; MGI: 88038; HomoloGene: 36067; GeneCards: FABP4; OMA:FABP4 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	81,483,236 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	10,273,636 bp
RNA expression pattern
	Top expressed in
	abdominal fat; ; pericardium; ; skin of hip; ; subcutaneous adipose tissue; ; vena cava; ; lactiferous duct; ; synovial joint; ; trabecular bone; ; gastric mucosa; ; thoracic diaphragm;
	Top expressed in
	intercostal muscle; ; tunica adventitia of aorta; ; transitional epithelium of urinary bladder; ; brown adipose tissue; ; tunica media of zone of aorta; ; parotid gland; ; decidua; ; gastrula; ; aortic valve; ; ascending aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	transporter activity; fatty acid binding; lipid binding; long-chain fatty acid transporter activity; long-chain fatty acid binding; hormone receptor binding;
Cellular component	cytosol; lipid droplet; extracellular exosome; nucleus; cytoplasm;
Biological process	white fat cell differentiation; regulation of inflammatory response; cytokine production; cholesterol homeostasis; positive regulation of inflammatory response; negative regulation of transcription, DNA-templated; cellular response to lithium ion; negative regulation of protein kinase activity; brown fat cell differentiation; triglyceride catabolic process; cellular response to tumor necrosis factor; transport; response to bacterium; long-chain fatty acid transport; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	2167
	11770
	ENSG00000170323
	ENSMUSG00000062515
	P15090
	P04117
	NM_001442
	NM_024406
	NP_001433
	NP_077717
	Wikidata
View/Edit Human	View/Edit Mouse

aP2 (adipocyte Protein 2) is a carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. aP2 is also called fatty acid binding protein 4 (FABP4). Blocking this protein either through genetic engineering or drugs has the possibility of treating heart disease and the metabolic syndrome.