ATP6V1G1

ATP6V1G1
Identifiers
Aliases	ATP6V1G1, ATP6G, ATP6G1, ATP6GL, ATP6J, Vma10, ATPase H+ transporting V1 subunit G1
External IDs	OMIM: 607296; MGI: 1913540; HomoloGene: 31272; GeneCards: ATP6V1G1; OMA:ATP6V1G1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	114,598,915 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	63,468,987 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; pylorus; ; cardia; ; ganglionic eminence; ; olfactory zone of nasal mucosa; ; retinal pigment epithelium; ; corpus epididymis; ; anterior pituitary; ; gonad; ; oral cavity;
	Top expressed in
	granulocyte; ; yolk sac; ; muscle of thigh; ; right kidney; ; spermatocyte; ; lip; ; ventricular zone; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ATPase binding; ATPase activity; P-type proton-exporting transporter activity; protein binding; ATPase-coupled transmembrane transporter activity;
Cellular component	cytosol; plasma membrane; intracellular anatomical structure; lysosomal membrane; vacuolar proton-transporting V-type ATPase complex; extracellular exosome;
Biological process	insulin receptor signaling pathway; transferrin transport; proton transmembrane transport; ion transport; ion transmembrane transport; regulation of macroautophagy; phagosome acidification; cellular iron ion homeostasis; cellular response to increased oxygen levels; transport;
	Sources:Amigo / QuickGO
Orthologs
	9550
	66290
	ENSG00000136888
	ENSMUSG00000039105
	O75348
	Q9CR51
	NM_004888
	NM_024173
	NP_004879; NP_004879.1
	NP_077135
	Wikidata
View/Edit Human	View/Edit Mouse

V-type proton ATPase subunit G 1 is an enzyme that in humans is encoded by the ATP6V1G1 gene.

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized.