| ATP6V1B2 |
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| Identifiers |
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| Aliases | ATP6V1B2, ATP6B1B2, ATP6B2, HO57, VATB, VPP3, Vma2, ATPase H+ transporting V1 subunit B2, DOOD, ZLS2 |
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| External IDs | OMIM: 606939; MGI: 109618; HomoloGene: 1279; GeneCards: ATP6V1B2; OMA:ATP6V1B2 - orthologs |
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| Gene location (Mouse) |
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| | Chr. | Chromosome 8 (mouse) |
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| | Band | 8|8 B3.3 | Start | 69,541,298 bp |
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| End | 69,566,363 bp |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - Pons
- monocyte
- lateral nuclear group of thalamus
- prefrontal cortex
- Brodmann area 10
- orbitofrontal cortex
- frontal pole
- pars compacta
- dorsolateral prefrontal cortex
- superior vestibular nucleus
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| | Top expressed in | - pontine nuclei
- perirhinal cortex
- central gray substance of midbrain
- entorhinal cortex
- cingulate gyrus
- CA3 field
- medial vestibular nucleus
- inferior colliculi
- primary motor cortex
- medial dorsal nucleus
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| | More reference expression data |
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| BioGPS | |
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| Wikidata |
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V-type proton ATPase subunit B, brain isoform is an enzyme that in humans is encoded by the ATP6V1B2 gene.
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts.
In melanocytic cells ATP6V1B2 gene expression may be regulated by MITF.
