ATOX1

ATOX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FE0, 1FE4, 1FEE, 1TL4, 1TL5, 2K1R, 2LQ9, 3CJK, 3IWL, 3IWX, 4QOT, 4YDX, 4YEA
Identifiers
Aliases	ATOX1, ATX1, HAH1, antioxidant 1 copper chaperone
External IDs	OMIM: 602270; MGI: 1333855; HomoloGene: 2984; GeneCards: ATOX1; OMA:ATOX1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	151,772,532 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	55,352,065 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; right lobe of liver; ; right adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; left lobe of thyroid gland; ; stromal cell of endometrium; ; right lobe of thyroid gland; ; olfactory zone of nasal mucosa; ; left coronary artery;
	Top expressed in
	yolk sac; ; right kidney; ; choroid plexus of fourth ventricle; ; lip; ; embryo; ; olfactory epithelium; ; hair follicle; ; skin of abdomen; ; left lobe of liver; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	copper ion transmembrane transporter activity; metallochaperone activity; copper ion binding; protein binding; copper chaperone activity; copper-dependent protein binding; metal ion binding; ATPase binding;
Cellular component	cytosol;
Biological process	metal ion transport; copper ion transport; ion transport; protein maturation by copper ion transfer; copper ion transmembrane transport; cellular copper ion homeostasis; response to oxidative stress; negative regulation of apoptotic process; copper ion export;
	Sources:Amigo / QuickGO
Orthologs
	475
	11927
	ENSG00000177556
	ENSMUSG00000018585
	O00244
	O08997
	NM_004045
	NM_009720
	NP_004036
	NP_033850
	Wikidata
View/Edit Human	View/Edit Mouse

ATOX1 is a copper metallochaperone protein that is encoded by the ATOX1 gene in humans. In mammals, ATOX1 plays a key role in copper homeostasis as it delivers copper from the cytosol to transporters ATP7A and ATP7B. Homologous proteins are found in a wide variety of eukaryotes, including Saccharomyces cerevisiae as ATX1, and all contain a conserved metal binding domain.