ASAH1

ASAH1
Identifiers
Aliases	ASAH1, AC, ACDase, ASAH, PHP, PHP32, SMAPME, N-acylsphingosine amidohydrolase (acid ceramidase) 1, N-acylsphingosine amidohydrolase 1
External IDs	OMIM: 613468; MGI: 1277124; HomoloGene: 10504; GeneCards: ASAH1; OMA:ASAH1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	18,084,998 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	41,827,810 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; visceral pleura; ; pancreatic ductal cell; ; retinal pigment epithelium; ; myocardium; ; parietal pleura; ; nasal epithelium; ; monocyte; ; renal medulla; ; left ventricle;
	Top expressed in
	saccule; ; stroma of bone marrow; ; endothelial cell of lymphatic vessel; ; otic placode; ; iris; ; calvaria; ; ciliary body; ; parotid gland; ; Epithelium of choroid plexus; ; epithelium of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	N-acylsphingosine amidohydrolase activity; catalytic activity; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; ceramidase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides;
Cellular component	lysosome; lysosomal lumen; extracellular exosome; extracellular region; extracellular space; tertiary granule lumen; ficolin-1-rich granule lumen; early endosome; endoplasmic reticulum; nucleus; cytoplasm;
Biological process	glycosphingolipid metabolic process; ceramide metabolic process; lipid metabolism; neutrophil degranulation; sphingosine biosynthetic process; ceramide biosynthetic process; ceramide catabolic process; keratinocyte differentiation; regulation of steroid biosynthetic process; regulation of programmed necrotic cell death; cellular response to tumor necrosis factor; sphingolipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	427
	11886
	ENSG00000104763
	ENSMUSG00000031591
	Q13510
	Q9WV54
	NM_001127505; NM_004315; NM_177924; NM_001363743
	NM_019734
	NP_001120977; NP_004306; NP_808592; NP_001350672
	NP_062708
	Wikidata
View/Edit Human	View/Edit Mouse

The ASAH1 gene encodes in humans the acid ceramidase enzyme.