ARHGEF6

ARHGEF6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UJY, 1WYR
Identifiers
Aliases	ARHGEF6, COOL2, Cool-2, MRX46, PIXA, alpha-PIX, alphaPIX, Rac/Cdc42 guanine nucleotide exchange factor 6
External IDs	OMIM: 300267; MGI: 1920591; HomoloGene: 3561; GeneCards: ARHGEF6; OMA:ARHGEF6 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	136,780,932 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	57,338,729 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; internal globus pallidus; ; vastus lateralis muscle; ; Skeletal muscle tissue of rectus abdominis; ; right ventricle; ; tibia; ; Achilles tendon; ; mononuclear cell; ; monocyte;
	Top expressed in
	gastrula; ; interventricular septum; ; mesenteric lymph nodes; ; granulocyte; ; calvaria; ; triceps brachii muscle; ; muscle of thigh; ; thymus; ; vastus lateralis muscle; ; medial head of gastrocnemius muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; GTPase activator activity; guanyl-nucleotide exchange factor activity;
Cellular component	cytosol; cell projection; lamellipodium;
Biological process	positive regulation of apoptotic process; JNK cascade; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; lamellipodium assembly; apoptotic process; positive regulation of GTPase activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9459
	73341
	ENSG00000129675
	ENSMUSG00000031133
	Q15052
	Q8K4I3
	NM_001306177; NM_004840
	NM_152801; NM_001358573
	NP_001293106; NP_004831
NP_690014; NP_001345502; NP_001392097; NP_001392098; NP_001392099;
	NP_001392100; NP_001392101; NP_001392102; NP_001392103; NP_001392104; NP_001392105
	Wikidata
View/Edit Human	View/Edit Mouse

Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene.

ARHGEF6 is commonly known as the p21-activated protein kinase exchange factor alpha (alpha-PIX or αPIX), because it was identified by binding to p21-activated kinase (PAK) and also contains a guanine nucleotide exchange factor domain.