ARHGEF4

ARHGEF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DX1, 2PZ1, 3NMX, 3NMZ
Identifiers
Aliases	ARHGEF4, ASEF, ASEF1, GEF4, STM6, Rho guanine nucleotide exchange factor 4, SMIM39
External IDs	OMIM: 605216; MGI: 2442507; HomoloGene: 49414; GeneCards: ARHGEF4; OMA:ARHGEF4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	131,047,263 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	34,813,309 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; nucleus accumbens; ; prefrontal cortex; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; Amygdala; ; putamen; ; caudate nucleus; ; Brodmann area 10;
	Top expressed in
	central gray substance of midbrain; ; pontine nuclei; ; dorsal tegmental nucleus; ; anterior horn of spinal cord; ; medial vestibular nucleus; ; superior colliculus; ; hippocampus proper; ; dentate gyrus; ; facial motor nucleus; ; nucleus of stria terminalis;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein domain specific binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; ruffle membrane; cytosol; plasma membrane; cell projection; membrane;
Biological process	filopodium assembly; regulation of Rho protein signal transduction; intracellular signal transduction; regulation of small GTPase mediated signal transduction; lamellipodium assembly; positive regulation of apoptotic process; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	50649
	226970
	ENSG00000136002
	ENSMUSG00000037509
	Q9NR80
	Q7TNR9
NM_015320; NM_032995; NM_001367493; NM_001375900; NM_001375901;
	NM_001375902; NM_001375903; NM_001375904; NM_001395416
	NM_183019; NM_001368773
NP_056135; NP_001354422; NP_001362829; NP_001362830; NP_001362831;
	NP_001362832; NP_001362833
	NP_898840; NP_001355702
	Wikidata
View/Edit Human	View/Edit Mouse

Rho guanine nucleotide exchange factor 4 is a protein that in humans is encoded by the ARHGEF4 gene.