APPBP1

NAE1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1R4M, 1R4N, 1TT5, 1YOV, 2NVU, 3DBH, 3DBL, 3DBR, 3GZN
Identifiers
Aliases	NAE1, A-116A10.1, APPBP1, ula-1, HPP1, NEDD8 activating enzyme E1 subunit 1
External IDs	OMIM: 603385; MGI: 2384561; HomoloGene: 68370; GeneCards: NAE1; OMA:NAE1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	66,873,256 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	105,261,269 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; gonad; ; Achilles tendon; ; ventricular zone; ; testicle; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; ganglionic eminence; ; tibia; ; skin of hip;
	Top expressed in
	primitive streak; ; spermatocyte; ; ciliary body; ; medial ganglionic eminence; ; Gonadal ridge; ; iris; ; abdominal wall; ; mandibular prominence; ; maxillary prominence; ; vestibular sensory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	NEDD8 activating enzyme activity; protein binding; ubiquitin-like modifier activating enzyme activity; ubiquitin protein ligase binding; protein heterodimerization activity;
Cellular component	cytoplasm; plasma membrane; membrane; cytosol; protein-containing complex;
Biological process	regulation of apoptotic process; neuron apoptotic process; cell cycle; protein neddylation; regulation of neuron apoptotic process; mitotic DNA replication checkpoint signaling; signal transduction; apoptotic process; post-translational protein modification; protein modification by small protein conjugation;
	Sources:Amigo / QuickGO
Orthologs
	8883
	234664
	ENSG00000159593
	ENSMUSG00000031878
	Q13564
	Q8VBW6
	NM_001018159; NM_001018160; NM_001286500; NM_003905
	NM_144931
	NP_001018169; NP_001018170; NP_001273429; NP_003896
	NP_659180
	Wikidata
View/Edit Human	View/Edit Mouse

NEDD8-activating enzyme E1 regulatory subunit is a protein that in humans is encoded by the NAE1 gene.