APBB1

APBB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E45, 2HO2, 2IDH, 3D8D, 3D8E, 3D8F, 3DXC, 3DXD, 3DXE
Identifiers
Aliases	APBB1, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65), FE65, MGC:9072, RIR, amyloid beta precursor protein binding family B member 1
External IDs	OMIM: 602709; MGI: 107765; HomoloGene: 898; GeneCards: APBB1; OMA:APBB1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	6,419,414 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	105,230,860 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; C1 segment; ; ganglionic eminence; ; prefrontal cortex; ; anterior pituitary; ; cingulate gyrus; ; Brodmann area 9; ; anterior cingulate cortex; ; Amygdala;
	Top expressed in
	entorhinal cortex; ; perirhinal cortex; ; primary visual cortex; ; CA3 field; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; habenula; ; primary motor cortex; ; cerebellar cortex; ; prefrontal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; histone binding; chromatin binding; protein binding; tau protein binding; proline-rich region binding; transcription factor binding; amyloid-beta binding; ubiquitin protein ligase binding;
Cellular component	postsynaptic membrane; nuclear speck; cell projection; membrane; dendritic spine; synapse; main axon; nucleoplasm; growth cone lamellipodium; soma; perinuclear region of cytoplasm; growth cone filopodium; presynaptic membrane; lamellipodium; plasma membrane; cytoplasm; growth cone; nucleus; protein-containing complex; presynapse;
Biological process	regulation of transcription, DNA-templated; axonogenesis; positive regulation of DNA repair; transcription, DNA-templated; response to iron ion; negative regulation of cell growth; positive regulation of protein secretion; positive regulation of neuron projection development; positive regulation of apoptotic process; signal transduction; positive regulation of transcription by RNA polymerase II; apoptotic process; histone H4 acetylation; positive regulation of transcription, DNA-templated; cellular response to DNA damage stimulus; double-strand break repair; negative regulation of transcription by RNA polymerase II; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	322
	11785
	ENSG00000166313
	ENSMUSG00000037032
	O00213
	Q9QXJ1
NM_001164; NM_001257319; NM_001257320; NM_001257321; NM_001257322;
	NM_001257323; NM_001257324; NM_001257325; NM_001257326; NM_145689
	NM_001253885; NM_001253886; NM_001253887; NM_009685; NM_001310600
NP_001155; NP_001244248; NP_001244249; NP_001244250; NP_001244252;
	NP_001244254; NP_001244255; NP_663722
	NP_001240814; NP_001240815; NP_001240816; NP_001297529; NP_033815
	Wikidata
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Amyloid beta A4 precursor protein-binding family B member 1 is a protein that in humans is encoded by the APBB1 gene.