ANKRD2

ANKRD2
Identifiers
Aliases	ANKRD2, ankyrin repeat domain 2 (stretch responsive muscle), ARPP, ankyrin repeat domain 2
External IDs	OMIM: 610734; MGI: 1861447; HomoloGene: 10568; GeneCards: ANKRD2; OMA:ANKRD2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	97,583,884 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	42,033,549 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; thoracic diaphragm; ; apex of heart; ; Skeletal muscle tissue of rectus abdominis; ; gastrocnemius muscle; ; left ventricle; ; Skeletal muscle tissue of biceps brachii; ; triceps brachii muscle; ; glutes; ; deltoid muscle;
	Top expressed in
	soleus muscle; ; ankle; ; intercostal muscle; ; digastric muscle; ; muscle of thigh; ; sternocleidomastoid muscle; ; tibialis anterior muscle; ; vastus lateralis muscle; ; gastrocnemius muscle; ; plantaris muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	chromatin binding; structural constituent of muscle; RNA polymerase II-specific DNA-binding transcription factor binding; titin binding; protein kinase B binding; transcription coregulator activity;
Cellular component	PML body; intracellular membrane-bounded organelle; cytoplasm; cytosol; euchromatin; myofibril; nucleus; sarcomere; I band;
Biological process	negative regulation of transcription by RNA polymerase II; regulation of cytokine production; muscle contraction; muscle organ development; negative regulation of myotube differentiation; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; regulation of intrinsic apoptotic signaling pathway by p53 class mediator; regulation of myoblast proliferation; negative regulation of myoblast differentiation; skeletal muscle cell differentiation; regulation of transcription by RNA polymerase II; myoblast differentiation; skeletal muscle tissue development;
	Sources:Amigo / QuickGO
Orthologs
	26287
	56642
	ENSG00000165887
	ENSMUSG00000025172
	Q9GZV1
	Q9WV06
	NM_020349; NM_001129981; NM_001291218; NM_001291219; NM_001346793
	NM_020033
	NP_001123453; NP_001278147; NP_001278148; NP_001333722; NP_065082
	NP_064417
	Wikidata
View/Edit Human	View/Edit Mouse

Ankyrin Repeat, PEST sequence and Proline-rich region (ARPP), also known as Ankyrin repeat domain-containing protein 2 is a protein that in humans is encoded by the ANKRD2 gene. ARPP is a member of the muscle ankyrin repeat proteins (MARP), which also includes CARP and DARP, and is highly expressed in cardiac and skeletal muscle and in other tissues. Expression of ARPP has been shown to be altered in patients with dilated cardiomyopathy and amyotrophic lateral sclerosis. A role for Ankrd2 in tumor progression and metastases spreading has also been described.