AKAP6

AKAP6
Identifiers
Aliases	AKAP6, ADAP100, ADAP6, AKAP100, PRKA6, mAKAP, A-kinase anchoring protein 6
External IDs	OMIM: 604691; MGI: 3050566; HomoloGene: 3157; GeneCards: AKAP6; OMA:AKAP6 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	32,837,684 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	53,202,382 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; prefrontal cortex; ; muscle of thigh; ; left ventricle; ; ventricular zone; ; Brodmann area 9; ; popliteal artery; ; tibial arteries; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	superior cervical ganglion; ; trigeminal ganglion; ; substantia nigra; ; facial motor nucleus; ; myocardium of ventricle; ; extraocular muscle; ; superior colliculus; ; nucleus of stria terminalis; ; Region I of hippocampus proper; ; inferior colliculi;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-membrane adaptor activity; transmembrane transporter binding; adenylate cyclase binding; protein kinase A binding; protein binding; molecular adaptor activity; protein kinase A regulatory subunit binding;
Cellular component	cytoplasm; nuclear membrane; nuclear envelope; calcium channel complex; membrane; intercalated disc; T-tubule; junctional sarcoplasmic reticulum membrane; sarcoplasmic reticulum; perinuclear region of cytoplasm; caveola; nucleus;
Biological process	protein targeting; positive regulation of release of sequestered calcium ion into cytosol; regulation of protein kinase A signaling; cellular response to cytokine stimulus; positive regulation of delayed rectifier potassium channel activity; positive regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of cell growth; positive regulation of potassium ion transmembrane transport; action potential; regulation of membrane repolarization; positive regulation of cell growth involved in cardiac muscle cell development; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; cAMP-mediated signaling; cellular response to cAMP; positive regulation of phosphoprotein phosphatase activity; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	9472
	238161
	ENSG00000151320
	ENSMUSG00000061603
	Q13023
	n/a
	NM_004274
	NM_198111
	NP_004265
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

A-kinase anchor protein 6 is an enzyme that in humans is encoded by the AKAP6 gene.

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum.