Angiotensin II receptor type 1

AGTR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4YAY, 4ZUD
Identifiers
Aliases	AGTR1, AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R, angiotensin II receptor type 1
External IDs	OMIM: 106165; MGI: 87964; HomoloGene: 3556; GeneCards: AGTR1; OMA:AGTR1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	148,743,008 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	30,566,850 bp
RNA expression pattern
	Top expressed in
	skin of hip; ; placenta; ; subcutaneous adipose tissue; ; liver; ; right lobe of liver; ; right adrenal gland; ; left adrenal gland; ; adrenal cortex; ; left adrenal cortex; ; right adrenal cortex;
	Top expressed in
	adrenal gland; ; interventricular septum; ; left lobe of liver; ; lumbar spinal ganglion; ; prostate; ; myocardium of ventricle; ; human kidney; ; lobe of prostate; ; right kidney; ; sciatic nerve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; angiotensin type II receptor activity; angiotensin type I receptor activity; signal transducer activity; bradykinin receptor binding; protein binding; protein heterodimerization activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; intracellular anatomical structure;
Biological process	positive regulation of protein metabolic process; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of inflammatory response; maintenance of blood vessel diameter homeostasis by renin-angiotensin; positive regulation of phospholipase A2 activity; regulation of renal sodium excretion; kidney development; positive regulation of cholesterol esterification; phospholipase C-activating angiotensin-activated signaling pathway; positive regulation of cytosolic calcium ion concentration; angiotensin-activated signaling pathway; renin-angiotensin regulation of aldosterone production; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of macrophage derived foam cell differentiation; positive regulation of reactive oxygen species metabolic process; regulation of vasoconstriction; low-density lipoprotein particle remodeling; regulation of cell population proliferation; regulation of cell growth; Rho protein signal transduction; positive regulation of NAD(P)H oxidase activity; regulation of inflammatory response; cell chemotaxis; regulation of systemic arterial blood pressure by renin-angiotensin; calcium-mediated signaling; signal transduction; blood vessel diameter maintenance; G protein-coupled receptor signaling pathway; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	185
	11607
	ENSG00000144891
	ENSMUSG00000049115
	P30556
	P29754
NM_032049; NM_000685; NM_004835; NM_009585; NM_031850;
	NM_001382736; NM_001382737
	NM_177322
NP_000676; NP_004826; NP_033611; NP_114038; NP_114438;
	NP_001369665; NP_001369666
	NP_796296
	Wikidata
View/Edit Human	View/Edit Mouse

Angiotensin II receptor type 1 (AT1) is a G_q/11-coupled G protein-coupled receptor (GPCR) and the best characterized angiotensin receptor. It is encoded in humans by the AGTR1 gene. AT1 has vasopressor effects and regulates aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. Angiotensin II receptor blockers are drugs indicated for hypertension, diabetic nephropathy and congestive heart failure.