AGGF1

AGGF1
Identifiers
Aliases	AGGF1, GPATC7, GPATCH7, HSU84971, HUS84971, VG5Q, angiogenic factor with G-patch and FHA domains 1
External IDs	OMIM: 608464; MGI: 1913799; HomoloGene: 41220; GeneCards: AGGF1; OMA:AGGF1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	77,065,234 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	95,511,860 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; epithelium of nasopharynx; ; palpebral conjunctiva; ; Brodmann area 23; ; germinal epithelium; ; visceral pleura; ; Skeletal muscle tissue of biceps brachii; ; parietal pleura; ; corpus epididymis; ; middle temporal gyrus;
	Top expressed in
	Gonadal ridge; ; vestibular membrane of cochlear duct; ; pineal gland; ; cumulus cell; ; Paneth cell; ; vas deferens; ; deep cerebellar nuclei; ; medial vestibular nucleus; ; medial dorsal nucleus; ; condyle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleic acid binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; extracellular region;
Biological process	vasculogenesis; multicellular organism development; cell differentiation; cell adhesion; positive regulation of endothelial cell proliferation; angiogenesis; positive regulation of angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	55109
	66549
	ENSG00000164252
	ENSMUSG00000021681
	Q8N302
	Q7TN31
	NM_018046; NM_013303; NM_138490
	NM_025630
	NP_060516
	NP_079906
	Wikidata
View/Edit Human	View/Edit Mouse

Angiogenic factor with G patch and FHA domains 1 is a protein that in humans is encoded by the AGGF1 gene.

AGGF1 is a human gene that functions as an angiogenic factor with a G-patch and forkhead-associated domain. This gene is predominantly expressed in activated, plump endothelial cells and acts to regulate angiogenesis and vascular development. AGGF1 is known to interact with a wide range of proteins involved in vascular development. Mutations to AGGF1 have been implicated in multiple cancers and is known to cause the rare congenital condition, Klippel-Trenaunay syndrome.