ADAM28

ADAM28
Identifiers
Aliases	ADAM28, ADAM 28, ADAM23, MDC-L, MDC-Lm, MDC-Ls, MDCL, eMDC II, eMDCII, ADAM metallopeptidase domain 28
External IDs	OMIM: 606188; MGI: 105988; HomoloGene: 40705; GeneCards: ADAM28; OMA:ADAM28 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	24,359,014 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	68,893,291 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; nasal epithelium; ; olfactory zone of nasal mucosa; ; gallbladder; ; pancreatic ductal cell; ; right uterine tube; ; epithelium of nasopharynx; ; mucosa of paranasal sinus; ; bronchial epithelial cell; ; appendix;
	Top expressed in
	superior surface of tongue; ; gallbladder; ; Ileal epithelium; ; nasal epithelium; ; olfactory epithelium; ; transitional epithelium of urinary bladder; ; corneal stroma; ; plantaris muscle; ; extensor digitorum longus muscle; ; interventricular septum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptidase activity; metalloendopeptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding;
Cellular component	integral component of membrane; extracellular region; membrane; mitochondrion; plasma membrane;
Biological process	spermatogenesis; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	10863
	13522
	ENSG00000042980
	ENSMUSG00000014725
	Q9UKQ2
	Q9JLN6
	NM_001304351; NM_014265; NM_021777
	NM_001048175; NM_010082; NM_176991; NM_183366
	NP_001291280; NP_055080; NP_068547
	NP_001041640; NP_034212; NP_899222
	Wikidata
View/Edit Human	View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 28 is an enzyme that in humans is encoded by the ADAM28 gene.

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell–matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. Alternative splicing results in two transcript variants. The shorter version encodes a secreted isoform, while the longer version encodes a transmembrane isoform.