ACTR1B

ACTR1B
Identifiers
Aliases	ACTR1B, ARP1B, CTRN2, PC3, ARP1 actin-related protein 1 homolog B, centractin beta, ARP1 actin related protein 1 homolog B, actin related protein 1B
External IDs	OMIM: 605144; MGI: 1917446; HomoloGene: 101541; GeneCards: ACTR1B; OMA:ACTR1B - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	97,664,044 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	36,753,503 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; right hemisphere of cerebellum; ; prefrontal cortex; ; body of pancreas; ; apex of heart; ; Brodmann area 9; ; right uterine tube; ; left adrenal cortex; ; right adrenal gland; ; body of uterus;
	Top expressed in
	superior frontal gyrus; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; muscle of thigh; ; yolk sac; ; cerebellar cortex; ; primary visual cortex; ; lip; ; right kidney; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; ATP binding; cytoskeletal protein-membrane anchor activity;
Cellular component	cytoplasm; microtubule cytoskeleton; cytosol; centrosome; extracellular exosome; cytoskeleton; membrane; dynactin complex; microtubule organizing center; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen; cell cortex region;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II; neutrophil degranulation; establishment of mitotic spindle orientation; nuclear migration along microtubule;
	Sources:Amigo / QuickGO
Orthologs
	10120
	226977
	ENSG00000115073
	ENSMUSG00000037351
	P42025
	Q8R5C5
	NM_005735
	NM_146107
	NP_005726
	NP_666219
	Wikidata
View/Edit Human	View/Edit Mouse

Beta-centractin is a protein that in humans is encoded by the ACTR1B gene.

This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins are of equal length and share 90% amino acid identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex.