ABRA (gene)

ABRA
Identifiers
Aliases	ABRA, STARS, actin binding Rho activating protein
External IDs	OMIM: 609747; MGI: 2444891; HomoloGene: 34713; GeneCards: ABRA; OMA:ABRA - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	106,770,244 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	41,733,116 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; deltoid muscle; ; right ventricle; ; muscle of thigh; ; gastrocnemius muscle; ; myocardium; ; body of tongue;
	Top expressed in
	interventricular septum; ; muscle of thigh; ; soleus muscle; ; knee joint; ; extraocular muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; digastric muscle; ; tibialis anterior muscle; ; gastrocnemius muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding;
Cellular component	cytoplasm; plasma membrane; sarcomere; myofibril; cytoskeleton; actin cytoskeleton;
Biological process	positive regulation of Rho protein signal transduction; protein transport; positive regulation of transcription, DNA-templated; positive regulation of DNA-binding transcription factor activity; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	137735
	223513
	ENSG00000174429
	ENSMUSG00000042895
	Q8N0Z2
	Q8BUZ1
	NM_139166
	NM_175456
	NP_631905
	NP_780665
	Wikidata
View/Edit Human	View/Edit Mouse

Actin-binding Rho-activating protein is a protein that in humans is encoded by the ABRA gene. The mouse and rat homologues are known as STARS (striated muscle activator of Rho signalling) and MS1 (myocyte stress 1) respectively.

MS1/STARS is regulated by MyoD during myogenic differentiation of the C2C12 cell line.