ABCA3

ABCA3
Identifiers
Aliases	ABCA3, ATP-binding cassette, sub-family A (ABC1), member 3, ABC-C, ABC3, EST111653, LBM180, SMDP3, ATP binding cassette subfamily A member 3
External IDs	OMIM: 601615; MGI: 1351617; HomoloGene: 37437; GeneCards: ABCA3; OMA:ABCA3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	2,340,746 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	24,629,175 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; upper lobe of lung; ; upper lobe of left lung; ; right hemisphere of cerebellum; ; frontal pole; ; paraflocculus of cerebellum; ; tendon of biceps brachii; ; prefrontal cortex; ; right frontal lobe; ; inferior olivary nucleus;
	Top expressed in
	left lung lobe; ; right lung; ; right lung lobe; ; human kidney; ; vestibular membrane of cochlear duct; ; transitional epithelium of urinary bladder; ; right kidney; ; Rostral migratory stream; ; facial motor nucleus; ; trigeminal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ATPase-coupled transmembrane transporter activity; nucleotide binding; ATPase activity; ATP binding; transporter activity; lipid transporter activity;
Cellular component	lamellar body membrane; integral component of membrane; plasma membrane; membrane; alveolar lamellar body membrane; alveolar lamellar body; extracellular space; intracellular membrane-bounded organelle;
Biological process	lipid transport; response to glucocorticoid; transmembrane transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	21
	27410
	ENSG00000167972
	ENSMUSG00000024130
	Q99758
	Q8R420
	NM_001089
	NM_001039581; NM_013855
	NP_001080
	NP_001034670; NP_038883
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-binding cassette sub-family A member 3 is a protein that in humans is encoded by the ABCA3 gene.

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death.