MTEP

MTEP
Identifiers
	IUPAC name 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine;
CAS Number	329205-68-7 ;
PubChem CID	9794218;
IUPHAR/BPS	3336;
ChemSpider	7969985 ;
UNII	XDA7P9K5S6;
CompTox Dashboard (EPA)	DTXSID30430775 ;
Chemical and physical data
Formula	C11H8N2S
Molar mass	200.26 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=NC(=CS1)C#CC2=CN=CC=C2;
	InChI InChI=1S/C11H8N2S/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10/h2-3,6-8H,1H3 ; Key:NRBNGHCYDWUVLC-UHFFFAOYSA-N ;
	(what is this?) (verify)

3-((2-Methyl-4-thiazolyl)ethynyl)pyridine (MTEP) is a research drug that was developed by Merck & Co. as a selective allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5. Identified through structure-activity relationship studies on an older mGluR5 antagonist MPEP, MTEP has subsequently itself acted as a lead compound for newer and even more improved drugs.

MTEP is both more potent and more selective than MPEP as a mGluR5 antagonist, and produces similar neuroprotective, antidepressant, analgesic, and anxiolytic effects but with either similar or higher efficacy depending on the test used.

MTEP also has similar efficacy to MPEP in reducing the symptoms of morphine withdrawal, and has anti-addictive effects in a variety of animal models, both reducing ethanol self-administration, and also decreasing the addictive effects of nicotine, cocaine and methamphetamine.

Identifiers


IUPAC name 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine
CAS Number	329205-68-7^Y
PubChem CID	9794218
IUPHAR/BPS	3336
ChemSpider	7969985^N
UNII	XDA7P9K5S6
CompTox Dashboard (EPA)	DTXSID30430775
Chemical and physical data
Formula	C₁₁H₈N₂S
Molar mass	200.26 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=NC(=CS1)C#CC2=CN=CC=C2
InChI InChI=1S/C11H8N2S/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10/h2-3,6-8H,1H3^N Key:NRBNGHCYDWUVLC-UHFFFAOYSA-N^N
^NY (what is this?) (verify)