25N-N1-Nap

25N-N1-Nap is a phenethylamine derivative from the 25-NB class, which acts as a potent agonist at the 5-HT_2A receptor with weaker activity at 5-HT_2B and 5-HT_2C. 25N-N1-Nap is a biased agonist, producing robust activation of 5-HT_2A coupled signaling pathways mediated by beta arrestin 2, but with little or no activation of pathways mediated via G_q. In animal studies it produces antipsychotic effects but without producing the head-twitch response associated with psychedelic activity.