2025 Mutua Madrid Open – Women's singles

Women's singles
2025 Mutua Madrid Open
Champion Aryna Sabalenka
Runner-up Coco Gauff
Score6–3, 7–6(7–3)
Draw96 (12Q, 8WC)
Seeds32

Aryna Sabalenka defeated Coco Gauff in the final, 6–3, 7–6(7–3) to win the women's singles tennis title at the 2025 Madrid Open. It was her third Madrid Open title, ninth WTA 1000 title, and 20th career WTA Tour title. Sabalenka was the second woman to win three singles titles at the tournament since its establishment in 2009, equaling Petra Kvitová.

Iga Świątek was the defending champion, but lost in the semifinals to Gauff.

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