2022 Ostrava Open – Singles

Singles
2022 Ostrava Open
Champion Barbora Krejčíková
Runner-up Iga Świątek
Score5–7, 7–6(7–4), 6–3
Draw28
Seeds8

Barbora Krejčíková defeated Iga Świątek in the final, 5–7, 7–6(7–4), 6–3 to win the singles tennis title at the 2022 Ostrava Open. It was Krejčíková's second WTA Tour title in back-to-back weeks, and she ended Świątek's streak of ten consecutive victories in WTA Tour finals. This marked only Świątek's second career loss in a WTA Tour-level final, out of twelve played (the other being at the 2019 Ladies Open Lugano).

Anett Kontaveit was the defending champion, but retired in the second round against Tereza Martincová.