2022 Australian Open – Mixed doubles
| Mixed doubles | |
|---|---|
| 2022 Australian Open | |
| Champions | Kristina Mladenovic Ivan Dodig |
| Runners-up | Jaimee Fourlis Jason Kubler |
| Score | 6–3, 6–4 |
Kristina Mladenovic and Ivan Dodig defeated Jaimee Fourlis and Jason Kubler in the final, 6–3, 6–4 to win the mixed doubles tennis title at the 2022 Australian Open. Though it was their first major title as a team, the win earned Mladenovic her third Mixed doubles title and Dodig his fourth.
Barbora Krejčíková and Rajeev Ram were the defending champions, but the three-time defending champion Krejčíková chose not to defend her title. Ram partnered alongside Sania Mirza, but they lost to Fourlis and Kubler in the quarterfinals.
Desirae Krawczyk was attempting to complete the first non-calendar-year Grand Slam in Mixed doubles since Billie Jean King in 1968 and would be the first in the Open Era, having won the French Open, Wimbledon and the US Open in 2021. However, she and her partner Joe Salisbury lost in the first round to Giuliana Olmos and Marcelo Arévalo.