2022 Astana Open – Singles
| Singles | |
|---|---|
| 2022 Astana Open | |
| Champion | Novak Djokovic |
| Runner-up | Stefanos Tsitsipas |
| Score | 6–3, 6–4 |
| Draw | 32 |
| Seeds | 8 |
Novak Djokovic defeated Stefanos Tsitsipas in the final, 6–3, 6–4 to win the singles tennis title at the 2022 Astana Open. It was his 90th ATP Tour-level singles title.
Kwon Soon-woo was the reigning champion, but chose to compete in Tokyo instead.