2021 Open Sud de France – Singles
| Singles | |
|---|---|
| 2021 Open Sud de France | |
| Champion | David Goffin |
| Runner-up | Roberto Bautista Agut |
| Score | 5–7, 6–4, 6–2 |
| Draw | 28 (4 Q / 3 WC ) |
| Seeds | 8 |
Gaël Monfils was the defending champion, but chose not to defend his title.
With the loss of Ugo Humbert in the quarterfinals, this was the first tournament without a French champion since 2017 when Alexander Zverev won the title. It was also the first without a French finalist since 2004. David Goffin won the title, defeating Roberto Bautista Agut in the final, 5–7, 6–4, 6–2.