2021 Mutua Madrid Open – Women's doubles
| Women's doubles | |
|---|---|
| 2021 Mutua Madrid Open | |
| Champions | Barbora Krejčíková Kateřina Siniaková |
| Runners-up | Gabriela Dabrowski Demi Schuurs |
| Score | 6–4, 6–3 |
Barbora Krejčíková and Kateřina Siniaková defeated Gabriela Dabrowski and Demi Schuurs in the final, 6–4, 6–3 to win the women's doubles tennis title at the 2021 Madrid Open. It marked the duo's seventh career WTA Tour doubles title together, as well as Krejčíková's eighth individual doubles title and Siniaková's 10th.
Hsieh Su-wei and Barbora Strýcová were the reigning champions from when the tournament was last held in 2019, but Strýcová did not return to compete due to her pregnancy. Hsieh partnered Elise Mertens; they lost in the second round to Jeļena Ostapenko and Anastasia Pavlyuchenkova. Despite the loss, Mertens usurped Hsieh for the WTA No. 1 doubles ranking.