2021 Abierto Mexicano Telcel – Singles
| Singles | |
|---|---|
| 2021 Abierto Mexicano Telcel | |
| Champion | Alexander Zverev |
| Runner-up | Stefanos Tsitsipas |
| Score | 6–4, 7–6(7–3) |
| Draw | 32 (4 Q / 3 WC ) |
| Seeds | 8 |
Alexander Zverev defeated top seed Stefanos Tsitsipas in the final, 6–4, 7–6(7–3) to win the men's singles tennis title at the 2021 Mexican Open.
Rafael Nadal was the defending champion, but chose not to defend his title.