2021–22 Coppa Italia Serie C
| Tournament details | |
|---|---|
| Country | Italy |
| Dates | 19 August 2021 – 6 April 2022 |
| Teams | 60 |
| Defending champions | Juventus U23 |
| Final positions | |
| Champions | Padova |
| Runners-up | Südtirol |
| Tournament statistics | |
| Matches played | 62 |
| Goals scored | 154 (2.48 per match) |
| Top goal scorer(s) | Nicolás Bubas Mattia Minesso (4 goals each) |
The 2021–22 Coppa Italia Serie C was the 49th season of the Coppa Italia Serie C, the cup competition for Serie C clubs.
Juventus U23 were the defending champions having won their first title in June 2020 against Ternana, with a 2–1 final score in the final.
The 2020–21 season was not held due to the COVID-19 pandemic.