2021–22 Moldovan National Division
| Season | 2021–22 |
|---|---|
| Dates | 1 July 2021 – 14 May 2022 |
| Champions | Sheriff 20th title |
| Relegated | Florești |
| Champions League | Sheriff |
| Conference League | Petrocub Milsami Sf. Gheorghe |
| Matches played | 112 |
| Goals scored | 343 (3.06 per match) |
| Top goalscorer | Vladimir Ambros (17 goals) |
| Best goalkeeper | Georgios Athanasiadis (13 clean sheets) |
| Biggest home win | Sheriff 7–0 Dinamo-Auto (28 November 2021) |
| Biggest away win | Dinamo-Auto 0–7 Sheriff (25 September 2021) |
| Highest scoring | Sheriff 7–1 Dinamo-Auto (7 August 2021) |
| Longest winning run | 9 matches Sheriff |
| Longest unbeaten run | 18 matches Sheriff |
| Longest winless run | 28 matches Florești |
| Longest losing run | 28 matches Florești |
← 2020–21 2022–23 → | |
The 2021–22 Moldovan National Division (Romanian: Divizia Națională) was the 31st season of top-tier football in Moldova. The season started on 1 July 2021 and ended on 14 May 2022. Sheriff Tiraspol were the defending champions. The winners of the league this season earned a spot in the first qualifying round of the 2022–23 UEFA Champions League, and the second, third and fourth placed clubs earned a place in the first qualifying round of the 2022–23 UEFA Europa Conference League.