2021–22 Greek Football Cup
| Tournament details | |
|---|---|
| Country | Greece |
| Teams | 119 |
| Defending champions | PAOK |
| Final positions | |
| Champions | Panathinaikos (19th title) |
| Runners-up | PAOK |
| Tournament statistics | |
| Matches played | 128 |
| Goals scored | 325 (2.54 per match) |
| Top goal scorer(s) | Vangelis Tsevanedis (6 goals) |
The 2021–22 Greek Football Cup was the 80th edition of the Greek Football Cup. The winner of the Cup qualified for the next season's Europa Conference League third qualifying round.