2021–22 Egyptian Second Division

Egyptian Second Division
Season	2021–22
Dates	30 September 2021 – 4 June 2022
Promoted	Group A:; Aswan; Group B:; El Dakhleya; Group C:; Haras El Hodoud;
Relegated	Group A:; Beni Suef; Sohag; Qena; Al Badari; Group B:; Al Merreikh; Port Fouad; Belbeis; Benha; Group C:; Ala'ab Damanhour; Al Zarka; Said El Mahalla; El Raja;
Matches played	720
Goals scored	1,644 (2.28 per match)
Top goalscorer	Rafik Kabou; (18 goals)
	← 2020–21 2022–23 →

The 2021–22 Egyptian Second Division was the 42nd edition of the Egyptian Second Division, the top Egyptian semi-professional level for football clubs, since its establishment in 1977. The season started on 30 September 2021 and concluded on 4 June 2022. Fixtures for the 2021–22 season were announced on 12 September 2021.

Aswan, El Dakhleya and Haras El Hodoud won Group A, Group B and Group C respectively and secured the promotion to the 2022–23 Egyptian Premier League.