2019 Western & Southern Open – Women's singles

Women's singles
2019 Western & Southern Open
Champion Madison Keys
Runner-up Svetlana Kuznetsova
Score7–5, 7–6(7–5)
Draw56 (12 Q / 5 WC )
Seeds16

Madison Keys defeated Svetlana Kuznetsova in the final, 7–5, 7–6(7–5) to win the women's singles tennis title at the 2019 Cincinnati Masters.

Kiki Bertens was the defending champion, but lost in the second round to Venus Williams.

Naomi Osaka retained the world No. 1 singles ranking after the tournament. Ashleigh Barty and Karolína Plíšková were also in contention for the top ranking.

This tournament marked Maria Sharapova's final WTA Tour-level victory before her retirement; she defeated Alison Riske in the first round before losing to Barty in the second round.