2016 Miami Open – Men's singles
| Men's singles | |
|---|---|
| 2016 Miami Open | |
| Champion | Novak Djokovic |
| Runner-up | Kei Nishikori |
| Score | 6–3, 6–3 |
| Draw | 96 (12 Q / 5 WC ) |
| Seeds | 32 |
Two-time defending champion Novak Djokovic defeated Kei Nishikori in the final, 6–3, 6–3 to win the men's singles tennis title at the 2016 Miami Open. Djokovic completed his record fourth Sunshine Double with the win, and won his record-equaling sixth Miami Open title. It was also his third consecutive Sunshine Double. He did not lose a single set in the entire tournament.
For the first time in tournament history, no Americans reached the last-of-16 stage.