2016 Italian Open – Women's singles

Women's singles
2016 Italian Open
Champion Serena Williams
Runner-up Madison Keys
Score7–6(7–5), 6–3
Draw56 (8 Q / 3 WC )
Seeds16

Serena Williams defeated Madison Keys in the final, 7–6(7–5), 6–3 to win the women's singles tennis title at the 2016 Italian Open. This was Williams's second title in Rome won without dropping a set, and her fourth Italian Open title overall.

Maria Sharapova was the reigning champion, but could not defend her title because of her provisional suspension after failing a drug test at the Australian Open.

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