2016 Italian Open – Men's doubles

Bob and Mike Bryan won the title, defeating Vasek Pospisil and Jack Sock in the final, 2–6, 6–3, [10–7]. They saved three match points in their opening match against Steve Johnson and Sam Querrey.

Pablo Cuevas and David Marrero were the defending champions, but Marrero chose not to participate this year. Cuevas played alongside Marcel Granollers, losing in the quarterfinals to Pospisil and Sock.