| 2016 Pac-12 Conference football season |
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| League | NCAA Division I Football Bowl Subdivision |
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| Sport | American football |
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| Number of teams | 12 |
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| TV partner(s) | Fox Sports Media Group (Fox, FS1), ESPN Family (ABC, ESPN, ESPN2, ESPNU), CBS (bowl game, and Pac-12 Networks |
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| Top draft pick | DE Solomon Thomas, Stanford |
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| Picked by | San Francisco 49ers, 3rd overall |
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| Top scorer | Cameron Van Winkle (123 points) |
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| North champions | Washington Huskies |
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| North runners-up | Washington State Cougars |
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| South champions | Colorado Buffaloes |
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| South runners-up | USC Trojans |
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| Champions | Washington Huskies |
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| Runners-up | Colorado Buffaloes |
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| Finals MVP | Taylor Rapp, DB |
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The 2016 Pac-12 Conference football season is the sixth season for the conference as a twelve-team league. The season began on August 26, 2016, with California vs. Hawaii. The final game was the 2016 Pac-12 Football Championship Game at Levi's Stadium on December 2, 2016, with Fox televising the game.