2013 Western & Southern Open – Men's singles

Men's singles
2013 Western & Southern Open
Champion Rafael Nadal
Runner-up John Isner
Score7–6(10–8), 7–6(7–3)

Rafael Nadal defeated John Isner in the final, 7–6(10–8), 7–6(7–3) to win the men's singles tennis title at the 2013 Cincinnati Open. It was his record-extending 26th Masters title.

Roger Federer was the defending champion, but lost in the quarterfinals to Nadal.