2011 US Open – Women's singles

Women's singles
2011 US Open
Champion Samantha Stosur
Runner-up Serena Williams
Score6–2, 6–3
Draw128
Seeds32

Samantha Stosur defeated Serena Williams in the final, 6–2, 6–3 to win the women's singles tennis title at the 2011 US Open. It was her first and only major singles title. Stosur was the first Australian woman to win a major since Evonne Goolagong Cawley at the 1980 Wimbledon Championships, and the first to win the US Open since Margaret Court in 1973.

Kim Clijsters was the two-time reigning champion, but withdrew due to an abdominal injury.

This was the first time in the tournament's history where no Americans were among the top ten seeds.

This tournament marked the first major appearance of future Australian Open champion Madison Keys, who was awarded a wildcard; she lost to Lucie Šafářová in the second round.