2010 Serbia Open – Singles
| Singles | |
|---|---|
| 2010 Serbia Open | |
| Champion | Sam Querrey |
| Runner-up | John Isner |
| Score | 3–6, 7–6(7–4), 6–4 |
Sam Querrey defeated John Isner in the final, 3–6, 7–6(7–4), 6–4 to win the singles tennis title at the 2010 Serbia Open.
Novak Djokovic was the defending champion, but retired in the quarterfinals against Filip Krajinović.