2010 French Open – Men's singles

Rafael Nadal defeated Robin Söderling in the final, 6–4, 6–2, 6–4 to win the men's singles tennis title at the 2010 French Open. It was his fifth French Open title and seventh major title overall. Nadal did not lose a set during the tournament for the second time (after 2008). By winning the title, Nadal regained the world No. 1 ranking from Roger Federer, who was in contention to break Pete Sampras' record of 286 weeks spent at the top position. He also completed a season sweep of the Monte-Carlo, Rome, Madrid, and French Open clay court tournaments.

Federer was the defending champion, but lost in the quarterfinals to Söderling in a rematch of the previous year's final. This marked the first time since the 2004 French Open that Federer did not reach the semifinals of a major, a span of 23 majors. Federer was attempting to become the first man in the Open Era and the third man ever to achieve a double career Grand Slam. Between the 2004 Wimbledon Championships and the 2017 Australian Open, this was the only major not to feature either Federer or Novak Djokovic in the semifinals. Djokovic's quarterfinal match against Jürgen Melzer marked the only time he lost a match at a major after leading two sets to love.