2004 NASDAQ-100 Open – Women's singles

Women's singles
2004 NASDAQ-100 Open
Champion Serena Williams
Runner-up Elena Dementieva
Score6–1, 6–1
Draw96 (9WC/12Q/2LL/6PR)
Seeds32

Two-time defending champion Serena Williams defeated Elena Dementieva in the final, 61, 61 to win the women's singles tennis title at the 2004 Miami Open.

This tournament marked the first career meeting between Serena Williams and Maria Sharapova; Williams won in straight sets in their fourth-round encounter.