1999 Italian Open – Women's singles

Women's singles
1999 Italian Open
Champion Venus Williams
Runner-up Mary Pierce
Score6–4, 6–2
Draw56
Seeds16

Venus Williams defeated Mary Pierce in the final, 6–4, 6–2 to win the women's singles tennis title at the 1999 Italian Open.

Martina Hingis was the defending champion, but lost in the semifinals to Williams in a rematch of the previous year's final.